AMP-activated protein kinase (AMPK) beyond metabolism
نویسندگان
چکیده
منابع مشابه
AMP-Activated Protein Kinase (AMPK) Regulates Energy Metabolism through Modulating Thermogenesis in Adipose Tissue
Obesity occurs when excess energy accumulates in white adipose tissue (WAT), whereas brown adipose tissue (BAT), which is specialized in dissipating energy through thermogenesis, potently counteracts obesity. White adipocytes can be converted to thermogenic "brown-like" cells (beige cells; WAT browning) under various stimuli, such as cold exposure. AMP-activated protein kinase (AMPK) is a cruci...
متن کاملMetformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms
People with Type 2 diabetes mellitus (T2DM) have reduced bone mineral density and an increased risk of fractures due to altered mesenchymal stem cell (MSC) differentiation in the bone marrow. This leads to a shift in the balance of differentiation away from bone formation (osteogenesis) in favour of fat cell development (adipogenesis). The commonly used anti-diabetic drug, metformin, activates ...
متن کاملBeyond energy homeostasis: the expanding role of AMP-activated protein kinase in regulating metabolism.
The recent exciting advances in our understanding of the regulation of the energy sensor AMP-activated protein kinase (AMPK), together with renewed appreciation of its importance in maintaining cellular function, brought together leading scientists at a recent FASEB-sponsored meeting in September 2014. Here, we report some of the highlights of this conference.
متن کاملRegulation of autophagy by AMP-activated protein kinase/ sirtuin 1 pathway reduces spinal cord neurons damage
Objective(s): AMP-activated protein kinase/sirtuin 1 (AMPK/SIRT1) signaling pathway has been proved to be involved in the regulation of autophagy in various models. The aim of this study was to evaluate the effect of AMPK/SIRT1 pathway on autophagy after spinal cord injury (SCI). Materials and Methods:The SCI model was established in rats in vivo and the primary spinal cord neurons were subject...
متن کاملRegulation of lipid metabolism by the AMP-activated protein kinase.
The AMP-activated protein kinase (AMPK) is the central component of a protein kinase cascade which plays an important role in the regulation of many different aspects of lipid metabolism [1,2]. AMPK is activated 50to 100-fold by phosphorylation by an upstream protein kinase, AMPK kinase (AMPKK) [3]. The key regulators of the AMPK cascade currently appear to be S’-AMP and ATP. AMP activates the ...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2013
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.26726